Kai (Jack) Zhang
Assistant Professor, Department of Molecular Biophysics and Biochemistry (MB&B)
Yale University
Date and time: December 11th, 2024 Wednesday at 8am PST / 11am EST / 4pm GMT / 5pm CET / 12am China
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High-resolution in situ structures of mammalian respiratory supercomplexes
Mitochondria are essential for ATP production via oxidative phosphorylation, involving respiratory complexes within the inner membrane. Despite extensive in vitro studies, understanding their mechanisms in physiological environment is challenging due to loss of the native environment during purification. Here, we directly image porcine mitochondria by developing a high-resolution in-situ cryo-electron microscopy technique, which enabled us to determine near-atomic structures of various respiratory supercomplexes in the native membrane.