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Organizers: Joakim Andén, Dorit Hanein, Roy R. Lederman and Steven J. Ludtke
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Antonio Martinez Sánchez
Professor in Computer Sciences, University of Murcia, Spain
Date and time: June 5th, 2024 Wednesday, at 8am PDT / 11am EDT / 3pm BST / 5pm CEST / 11pm China
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Fast Normalized Cross-Correlation for Template Matching with Rotations
Object detection is a main task in computer vision. Template matching is the reference method for detecting objects with arbitrary templates. However, template matching computational complexity depends on the rotation accuracy, being a limiting factor for large 3D images (tomograms).
Here, we implement a new algorithm called tensorial template matching, based on a mathematical framework that represents all rotations of a template with a tensor field. Contrary to standard template matching, the computational complexity of the presented algorithm is independent of the rotation accuracy.
Using both, synthetic and real data from cryo-electron tomography, we demonstrate that tensorial template matching is much faster than template matching and has the potential to improve its accuracy.
Last Talk
![](https://cryoem.world/wp-content/uploads/2024/05/Rangan_Adi.jpg)
Aaditya Rangan
Associate Professor, Courant Institute, New York University and Flatiron Institute.
Date and time: May 8th, 2024 Wednesday, at 8am PDT / 11am EDT / 3pm BST / 5pm CEST / 11pm China
Ab-initio Reconstruction from small datasets: using entropy-maximization and principal modes (EMPM).
In this talk I’ll describe a simple algorithm for obtaining a low-resolution model from a small number (~1000) picked-particle images. The algorithm (termed EMPM) is similar to classical alternating-minimization, but with a slight twist: the entropy of the viewing-angle distribution is maximized during the search. This entropy-maximization greatly improves robustness and accuracy, allowing EMPM to outperform many existing ab-initio reconstruction algorithms. Because of its low computational overhead, this algorithm could facilitate statistical strategies such as bootstrapping and cross-validation, along with the rapid assessment of particle quality.
![](https://cryoem.world/wp-content/uploads/2024/05/Clip_of_Figure-1024x581.jpg)