Peter Van Blerkom
Researcher
UC Santa Barbara
Date and time: October 8th, 2025 Wednesday at 8am PST / 11am EST / 4pm GMT / 5pm CET / 12am China
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The GoldX Fiducial Eraser
Gold nanoparticles are standard fiducial markers in cryogenic electron tomography but often cause reconstruction artifacts due to their high electron density. We present a post-processing tool that automatically detects and suppresses these particles by replacing them with the local background. The method yields cleaner tomograms without loss of sample information or introduction of new artifacts, enabling more accurate visualization and interpretation of native cellular structures.
References:
Van Blerkom P, Bezault A, Sauvanet C, Hanein D, Volkmann N. The GoldX Fiducial Eraser. International Journal of Molecular Sciences. 2024; 25(13):7442. https://doi.org/10.3390/ijms25137442