Jasenko Zivanov
MRC Laboratory of Molecular Biology, Cambridge
Bayesian Particle-Polishing in Detail
Date and time: 10/7/2020 Wednesday, at 8am PT / 11am ET/ 4pm BST / 5pm CEST / 11pm China
Registration required: https://yale.zoom.us/meeting/register/tJApcu6grD4iGdFaQsDVdpJEaGD1oE-3VOjB
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The beam-induced motion-correction method informally known as Bayesian Polishing will be discussed in detail. The method has been made available to the public in 2019 as part of Relion-3 and has been widely adopted since. The talk will focus on the Bayesian formulation of the problem and on the use of Gaussian processes to model our prior assumptions on the movement of particles embedded in the ice. A more recent adaptation of the method to estimate 3D motion in tomographic samples will also be briefly presented.
Zivanov, Jasenko, Takanori Nakane, and Sjors HW Scheres. “A Bayesian approach to beam-induced motion correction in cryo-EM single-particle analysis.” IUCrJ 6.1 (2019): 5-17.